Publications

Featured Publications

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Fitz-James et al. Mol Cell 85:667-691.e6 (2024)

Interchromosomal contacts between regulatory regions triggers stable transgenerational epigenetic inheritance in Drosophila 

 

In this paper we demonstrated the role of chromatin contacts in establishing epigenetic inheritance in Drosophila, developing a synthetic biology system to artificially induce chromatin contacts between two distant loci in vivo.

 

Research Publications

Fitz-James, M.H., Sparrow, P., Patton, C., Sarkis, P. Polycomb-mediated transgenerational epigenetic inheritance of Drosophila eye colour is independent of small RNAs, Open Biology 15:240298 (2025)

 

Sabarís, G., Schuettengruber, B., Papadopoulos, G. L., Coronado-Zamora, M., Fitz-James, M.H., Gonzalez, J., Cavalli, G. A mechanistic basis of genetic assimilation in natural fly populations, PNAS 122:e2415982122 (2025)

 

Fitz-James, M.H., Sabarís, G., Sarkis, P., Bantignies, F., Cavalli, G. Interchromosomal contacts between regulatory regions triggers stable transgenerational epigenetic inheritance in Drosophila, Mol Cell 85:667-691.e6 (2024)

 

Fitz-James, M.H., Tong, P., Pidoux, A.L., Ozadam, H., Yang, L., White, S.A., Dekker, J, Allshire, R.C. Large domains of heterochromatin direct the formation of short mitotic chromosome loops, eLife 9:e57212 (2020)

Review Publications

Fitz-James, M.H., Sabarís, G., Cavalli, G. Epigenetic inheritance in adaptive evolution, Ann NY Acad Sci 1524:22-29 (2023)

 

Fitz-James, M.H., Cavalli, G. Molecular mechanisms of transgenerational epigenetic inheritance. Nat Rev Genet 23:325-341 (2022)